@article {86,
	title = {Iron oxide nanoparticles induce Pseudomonas aeruginosa growth, induce biofilm formation, and inhibit antimicrobial peptide function.},
	journal = {Environmental Science: Nano},
	volume = {1},
	year = {2014},
	note = {CAPLUS AN 2014:465811(Journal; Online Computer File)},
	pages = {123 - 132},
	publisher = {Royal Society of Chemistry},
	abstract = {Given the increased use of iron-contg. nanoparticles in a no. of applications, it is important to understand any effects that iron-contg. nanoparticles can have on the environment and human health.  Since iron concns. are extremely low in body fluids, there is potential that iron-contg. nanoparticles may influence the ability of bacteria to scavenge iron for growth, affect virulence and inhibit antimicrobial peptide (AMP) function.  In this study, Pseudomonas aeruginosa (PA01) and AMPs were exposed to iron oxide nanoparticles, hematite (α-Fe2O3), of different sizes ranging from 2 to 540 nm (2 {\textpm} 1, 43 {\textpm} 6, 85 {\textpm} 25 and 540 {\textpm} 90 nm) in diam.  Here we show that the greatest effect on bacterial growth, biofilm formation, and AMP function impairment is found when exposed to the smallest particles.  These results are attributed in large part to enhanced dissoln. obsd. for the smallest particles and an increase in the amt. of bioavailable iron.  Furthermore, AMP function can be addnl. impaired by adsorption onto nanoparticle surfaces.  In particular, lysozyme readily adsorbs onto the nanoparticle surface which can lead to loss of peptide activity.  Thus, this current study shows that co-exposure of nanoparticles and known pathogens can impact host innate immunity.  Therefore, it is important that future studies be designed to further understand these types of impacts. [on SciFinder(R)]},
	keywords = {Pseudomonas iron oxide nanoparticle biofilm antimicrobial peptide},
	isbn = {2051-8161},
	author = {Borcherding, Jennifer and Baltrusaitis, Jonas and Chen, Haihan and Stebounova, Larissa and Wu, Chia-Ming and Rubasinghege, Gayan and Mudunkotuwa, Imali A. and Caraballo, Juan Carlos and Zabner, Joseph and Grassian, Vicki H. and Comellas, Alejandro P.}
}
@article {109,
	title = {Inside versus Outside: Ion Redistribution in Nitric Acid Reacted Sea Spray Aerosol Particles as Determined by Single Particle Analysis.},
	journal = {Journal of the American Chemical Society},
	volume = {135},
	year = {2013},
	note = {CAPLUS AN 2013:1428969(Journal; Online Computer File)},
	pages = {14528 - 14531},
	publisher = {American Chemical Society},
	abstract = {Single particle anal. of individual sea spray aerosol particles showed cations (Na+, K+, Mg2+, Ca2+) within individual particles undergo a spatial redistribution following heterogeneous reaction with HNO3, along with development of a more concd. layer of org. matter at the particle surface.  These data suggested specific ion and aerosol pH effects play an important role in aerosol particle structure in ways not previously recognized. [on SciFinder(R)]},
	keywords = {ion redistribution sea spray aerosol particle nitric acid reaction, single particle analysis monitoring ion redistribution sea spray aerosol},
	isbn = {0002-7863},
	author = {Ault, Andrew P. and Guasco, Timothy L. and Ryder, Olivia S. and Baltrusaitis, Jonas and Cuadra-Rodriguez, Luis A. and Collins, Douglas B. and Ruppel, Matthew J. and Bertram, Timothy H. and Prather, Kimberly A. and Grassian, Vicki H.}
}
@article {153,
	title = {Induction of Inflammasome-dependent Pyroptosis by Carbon Black Nanoparticles.},
	journal = {Journal of Biological Chemistry},
	volume = {286},
	year = {2011},
	note = {CAPLUS AN 2011:737835(Journal)},
	month = {2011///},
	pages = {21844 - 21852},
	publisher = {American Society for Biochemistry and Molecular Biology},
	abstract = {Inhalation of nanoparticles has been implicated in respiratory morbidity and mortality.  In particular, carbon black nanoparticles are found in many different environmental exposures.  Macrophages take up inhaled nanoparticles and respond via release of inflammatory mediators and in some cases cell death.  Based on new data, we propose that exposure of macrophages (both a macrophage cell line and primary human alveolar macrophages) to carbon black nanoparticles induces pyroptosis, an inflammasome-dependent form of cell death.  Exposure of macrophages to carbon black nanoparticles resulted in inflammasome activation as defined by cleavage of caspase 1 to its active form and downstream IL-1β release.  The cell death that occurred with carbon black nanoparticle exposure was identified as pyroptosis by the protective effect of a caspase 1 inhibitor and a pyroptosis inhibitor.  These data demonstrate that carbon black nanoparticle exposure activates caspase 1, increases IL-1β release after LPS priming, and induces the proinflammatory cell death, pyroptosis.  The identification of pyroptosis as a cellular response to carbon nanoparticle exposure is novel and relates to environmental and health impacts of carbon-based particulates. [on SciFinder(R)]},
	keywords = {carbon black nanoparticle immunotoxicity inflammasome pyroptosis},
	isbn = {0021-9258},
	author = {Reisetter, Anna C. and Stebounova, Larissa V. and Baltrusaitis, Jonas and Powers, Linda and Gupta, Amit and Grassian, Vicki H. and Monick, Martha M.}
}
