@article {113,
	title = {Product-to-parent reversion of trenbolone: Unrecognized risks for endocrine disruption.},
	journal = {Science (Washington, DC, United States)},
	volume = {342},
	year = {2013},
	note = {CAPLUS AN 2013:1616444(Journal)},
	pages = {347 - 351},
	publisher = {American Association for the Advancement of Science},
	abstract = {Trenbolone acetate (TBA) is a high-value steroidal growth promoter often administered to beef cattle, whose metabolites are potent endocrine-disrupting compds.  We performed lab. and field phototransformation expts. to assess the fate of TBA metabolites and their photoproducts.  Unexpectedly, we obsd. that the rapid photohydration of TBA metabolites is reversible under conditions representative of those in surface waters (pH 7, 25{\textdegree}C).  This product-to-parent reversion mechanism results in diurnal cycling and substantial regeneration of TBA metabolites at rates that are strongly temp.- and pH-dependent.  Photoproducts can also react to produce structural analogs of TBA metabolites.  These reactions also occur in structurally similar steroids, including human pharmaceuticals, which suggests that predictive fate models and regulatory risk assessment paradigms must account for transformation products of high-risk environmental contaminants such as endocrine-disrupting steroids. [on SciFinder(R)]},
	keywords = {trenbolone metabolite reversion endocrine disruption environment risk},
	isbn = {0036-8075},
	author = {Qu, Shen and Kolodziej, Edward P. and Long, Sarah A. and Gloer, James B. and Patterson, Eric V. and Baltrusaitis, Jonas and Jones, Gerrad D. and Benchetler, Peter V. and Cole, Emily A. and Kimbrough, Kaitlin C. and Tarnoff, Matthew D. and Cwiertny, David M.}
}
