<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Borcherding, Jennifer</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Chen, Haihan</style></author><author><style face="normal" font="default" size="100%">Stebounova, Larissa</style></author><author><style face="normal" font="default" size="100%">Wu, Chia-Ming</style></author><author><style face="normal" font="default" size="100%">Rubasinghege, Gayan</style></author><author><style face="normal" font="default" size="100%">Mudunkotuwa, Imali A.</style></author><author><style face="normal" font="default" size="100%">Caraballo, Juan Carlos</style></author><author><style face="normal" font="default" size="100%">Zabner, Joseph</style></author><author><style face="normal" font="default" size="100%">Grassian, Vicki H.</style></author><author><style face="normal" font="default" size="100%">Comellas, Alejandro P.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Iron oxide nanoparticles induce Pseudomonas aeruginosa growth, induce biofilm formation, and inhibit antimicrobial peptide function.</style></title><secondary-title><style face="normal" font="default" size="100%">Environmental Science: Nano</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Pseudomonas iron oxide nanoparticle biofilm antimicrobial peptide</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year></dates><publisher><style face="normal" font="default" size="100%">Royal Society of Chemistry</style></publisher><volume><style face="normal" font="default" size="100%">1</style></volume><pages><style face="normal" font="default" size="100%">123 - 132</style></pages><isbn><style face="normal" font="default" size="100%">2051-8161</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Given the increased use of iron-contg. nanoparticles in a no. of applications, it is important to understand any effects that iron-contg. nanoparticles can have on the environment and human health.  Since iron concns. are extremely low in body fluids, there is potential that iron-contg. nanoparticles may influence the ability of bacteria to scavenge iron for growth, affect virulence and inhibit antimicrobial peptide (AMP) function.  In this study, Pseudomonas aeruginosa (PA01) and AMPs were exposed to iron oxide nanoparticles, hematite (α-Fe2O3), of different sizes ranging from 2 to 540 nm (2 ± 1, 43 ± 6, 85 ± 25 and 540 ± 90 nm) in diam.  Here we show that the greatest effect on bacterial growth, biofilm formation, and AMP function impairment is found when exposed to the smallest particles.  These results are attributed in large part to enhanced dissoln. obsd. for the smallest particles and an increase in the amt. of bioavailable iron.  Furthermore, AMP function can be addnl. impaired by adsorption onto nanoparticle surfaces.  In particular, lysozyme readily adsorbs onto the nanoparticle surface which can lead to loss of peptide activity.  Thus, this current study shows that co-exposure of nanoparticles and known pathogens can impact host innate immunity.  Therefore, it is important that future studies be designed to further understand these types of impacts. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2014:465811(Journal; Online Computer File)</style></notes></record></records></xml>