<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sharma, Lohit</style></author><author><style face="normal" font="default" size="100%">Upadhyay, Ronak</style></author><author><style face="normal" font="default" size="100%">Rangarajan, Srinivas</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitor, co-catalyst, or co-reactant? Probing the different roles of H2S during CO2 hydrogenation on MoS2 catalyst</style></title><secondary-title><style face="normal" font="default" size="100%">ACS CatalysisACS Catalysis</style></secondary-title><short-title><style face="normal" font="default" size="100%">ACS Catal.</style></short-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019/09/20</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://doi.org/10.1021/acscatal.9b02986</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">American Chemical Society</style></publisher><language><style face="normal" font="default" size="100%">eng</style></language><notes><style face="normal" font="default" size="100%">doi: 10.1021/acscatal.9b02986</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Taifan, William</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Situ Spectroscopic Insights on the Molecular Structure of the MgO/SiO2 Catalytic Active Sites during Ethanol Conversion to 1,3-Butadiene</style></title><secondary-title><style face="normal" font="default" size="100%">The Journal of Physical Chemistry C</style></secondary-title><short-title><style face="normal" font="default" size="100%">J. Phys. Chem. C</style></short-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018/09/13</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://doi.org/10.1021/acs.jpcc.8b06767</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">American Chemical Society</style></publisher><volume><style face="normal" font="default" size="100%">122</style></volume><pages><style face="normal" font="default" size="100%">20894 - 20906</style></pages><isbn><style face="normal" font="default" size="100%">1932-7447</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><issue><style face="normal" font="default" size="100%">36</style></issue><notes><style face="normal" font="default" size="100%">doi: 10.1021/acs.jpcc.8b06767</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Peng, Rui</style></author><author><style face="normal" font="default" size="100%">Lin, Cuikun</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Wu, Chia-Ming</style></author><author><style face="normal" font="default" size="100%">Dimitrijevic, Nada M.</style></author><author><style face="normal" font="default" size="100%">Rajh, Tijana</style></author><author><style face="normal" font="default" size="100%">May, Stanley</style></author><author><style face="normal" font="default" size="100%">Koodali, Ranjit T.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Insight into band positions and inter-particle electron transfer dynamics between CdS nanoclusters and spatially isolated TiO2 dispersed in cubic MCM-48 mesoporous materials: a highly efficient system for photocatalytic hydrogen evolution under visible li</style></title><secondary-title><style face="normal" font="default" size="100%">Physical Chemistry Chemical Physics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">band position electron transfer cadmium sulfide titania MCM48</style></keyword><keyword><style  face="normal" font="default" size="100%">photocatalysis hydrogen evolution visible light</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year></dates><publisher><style face="normal" font="default" size="100%">Royal Society of Chemistry</style></publisher><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">2048 - 2061</style></pages><isbn><style face="normal" font="default" size="100%">1463-9076</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">CdS incorporated Si-MCM-48 and Ti-MCM-48 cubic phased mesoporous photocatalysts were prepd. by a two-step modification synthetic approach under relatively mild conditions.  A highly efficient (24.8%, apparent quantum yield (AQY)) photocatalyst for visible light (λ &gt; 400 nm) enabled solar hydrogen evolution can be realized by assembling CdS with Ti-MCM-48 cubic mesoporous materials in the absence of a noble metal co-catalyst.  The photocatalytic mechanism was thoroughly investigated and demonstrated by conducting a wealth of characterization techniques such as powder X-ray diffraction (XRD), nitrogen adsorption isotherm, transmission electron microscopy (TEM), UV-visible diffuse reflectance spectroscopy (DRS), XPS, UPS (UVPS), at. absorption spectroscopy (AAS), photoluminescence (PL) spectroscopy, time-resolved fluorescence emission decay, and ESR (EPR) spectroscopy studies.  This work is the first to unambiguously identify the band positions of both CdS and TiO2 encapsulated in porous materials.  The photocatalytic activity of the CdS incorporated Ti-MCM-48 mesoporous photocatalysts was found to be dependent on the content of both CdS and TiO2.  A correlation between the electron injection efficiency and the photocatalytic activity was established as well in the CdS incorporated Ti-MCM-48 mesoporous photocatalysts. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2014:16774(Journal; Online Computer File)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Borcherding, Jennifer</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Chen, Haihan</style></author><author><style face="normal" font="default" size="100%">Stebounova, Larissa</style></author><author><style face="normal" font="default" size="100%">Wu, Chia-Ming</style></author><author><style face="normal" font="default" size="100%">Rubasinghege, Gayan</style></author><author><style face="normal" font="default" size="100%">Mudunkotuwa, Imali A.</style></author><author><style face="normal" font="default" size="100%">Caraballo, Juan Carlos</style></author><author><style face="normal" font="default" size="100%">Zabner, Joseph</style></author><author><style face="normal" font="default" size="100%">Grassian, Vicki H.</style></author><author><style face="normal" font="default" size="100%">Comellas, Alejandro P.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Iron oxide nanoparticles induce Pseudomonas aeruginosa growth, induce biofilm formation, and inhibit antimicrobial peptide function.</style></title><secondary-title><style face="normal" font="default" size="100%">Environmental Science: Nano</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Pseudomonas iron oxide nanoparticle biofilm antimicrobial peptide</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year></dates><publisher><style face="normal" font="default" size="100%">Royal Society of Chemistry</style></publisher><volume><style face="normal" font="default" size="100%">1</style></volume><pages><style face="normal" font="default" size="100%">123 - 132</style></pages><isbn><style face="normal" font="default" size="100%">2051-8161</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Given the increased use of iron-contg. nanoparticles in a no. of applications, it is important to understand any effects that iron-contg. nanoparticles can have on the environment and human health.  Since iron concns. are extremely low in body fluids, there is potential that iron-contg. nanoparticles may influence the ability of bacteria to scavenge iron for growth, affect virulence and inhibit antimicrobial peptide (AMP) function.  In this study, Pseudomonas aeruginosa (PA01) and AMPs were exposed to iron oxide nanoparticles, hematite (α-Fe2O3), of different sizes ranging from 2 to 540 nm (2 ± 1, 43 ± 6, 85 ± 25 and 540 ± 90 nm) in diam.  Here we show that the greatest effect on bacterial growth, biofilm formation, and AMP function impairment is found when exposed to the smallest particles.  These results are attributed in large part to enhanced dissoln. obsd. for the smallest particles and an increase in the amt. of bioavailable iron.  Furthermore, AMP function can be addnl. impaired by adsorption onto nanoparticle surfaces.  In particular, lysozyme readily adsorbs onto the nanoparticle surface which can lead to loss of peptide activity.  Thus, this current study shows that co-exposure of nanoparticles and known pathogens can impact host innate immunity.  Therefore, it is important that future studies be designed to further understand these types of impacts. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2014:465811(Journal; Online Computer File)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kolodziej, Edward P.</style></author><author><style face="normal" font="default" size="100%">Qu, Shen</style></author><author><style face="normal" font="default" size="100%">Forsgren, Kristy L.</style></author><author><style face="normal" font="default" size="100%">Long, Sarah A.</style></author><author><style face="normal" font="default" size="100%">Gloer, James B.</style></author><author><style face="normal" font="default" size="100%">Jones, Gerrad D.</style></author><author><style face="normal" font="default" size="100%">Schlenk, Daniel</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Cwiertny, David M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification and Environmental Implications of Photo-Transformation Products of Trenbolone Acetate Metabolites.</style></title><secondary-title><style face="normal" font="default" size="100%">Environmental Science &amp; Technology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">photodegrdn trenbolone acetate metabolite Oryzias ecotoxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society</style></publisher><volume><style face="normal" font="default" size="100%">47</style></volume><pages><style face="normal" font="default" size="100%">5031 - 5041</style></pages><isbn><style face="normal" font="default" size="100%">0013-936X</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Despite the widespread use of the anabolic androgen trenbolone acetate (TBA) in animal agriculture, evidence demonstrating the occurrence of TBA metabolites such as 17β-trenbolone (17β-TBOH), 17α-trenbolone (17α-TBOH), and trendione (TBO) is relatively scarce, potentially due to rapid transformation processes such as direct photolysis.  Therefore, we investigated the phototransformation of TBA metabolites and assocd. ecol. implications by characterizing the photoproducts arising from the direct photolysis of 17β-TBOH, 17α-TBOH, and TBO and their assocd. ecotoxicity.  LC-HRMS/MS anal. identified a range of hydroxylated products that were no longer photoactive, with primary photoproducts consisting of monohydroxy species and presumptive diastereomers.  Also obsd. were higher-order hydroxylated products probably formed via subsequent reaction of primary photoproducts.  NMR anal. confirmed the formation of 12,17-dihydroxy-estra-5(10),9(11),dien-3-one (12-hydroxy-TBOH; 2.2 mg), 10,12,17-trihydroxy-estra-4,9(11),dien-3-one (10,12-dihydroxy-TBOH; 0.7 mg), and a ring-opened 11,12-dialdehyde oxidn. product (TBOH-11,12-dialdehyde; 1.0 mg) after irradn. of ∼14 mg of 17β-trenbolone.  Though unconfirmed by NMR, our data suggest that the formation of addnl. isomeric products may occur, likely due to the reactivity of the unique 4,9,11 conjugated triene structure of trenbolone.  In vivo exposure studies employing Japanese medaka (Oryzias latipes) indicate that low concns. of 17α-TBOH photoproduct mixts. can alter ovarian follicular development, and photoproducts alter whole-body 17β-estradiol levels.  Therefore, direct photolysis yields photoproducts with strong structural similarity to parent steroids, and these photoproducts still retain enough biol. activity to elicit observable changes to endocrine function at trace concns.  These data indicate that environmental transformation processes do not necessarily reduce steroid hormone ecotoxicity. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">10</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2013:623700(Journal; Online Computer File)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rasalingam, Shivatharsiny</style></author><author><style face="normal" font="default" size="100%">Kibombo, Harrison S.</style></author><author><style face="normal" font="default" size="100%">Wu, Chia-Ming</style></author><author><style face="normal" font="default" size="100%">Budhi, Sridhar</style></author><author><style face="normal" font="default" size="100%">Peng, Rui</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Koodali, Ranjit T.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Influence of Ti-O-Si hetero-linkages in the photocatalytic degradation of Rhodamine B.</style></title><secondary-title><style face="normal" font="default" size="100%">Catalysis Communications</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">titania silica xerogel visible light photocatalyst</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year></dates><publisher><style face="normal" font="default" size="100%">Elsevier B.V.</style></publisher><volume><style face="normal" font="default" size="100%">31</style></volume><pages><style face="normal" font="default" size="100%">66 - 70</style></pages><isbn><style face="normal" font="default" size="100%">1566-7367</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The influence of Ti-O-Si hetero-linkages in the degrdn. of Rhodamine B (RhB) dye over TiO2-SiO2 xerogels is exemplified by XPS anal.  The authors demonstrate a relationship between the percentage surface content of Ti-O-Si and the rate of photocatalytic degrdn. of RhB.  The authors detailed surface investigation revealed that the overall degrdn. of RhB is enhanced due to the high surface percentage content of Ti-O-Si species, high crystallinity of titania phase, and its effective dispersion on a high surface area porous silica support. [on SciFinder(R)]</style></abstract><notes><style face="normal" font="default" size="100%">CAPLUS AN 2013:15798(Journal; Online Computer File)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ault, Andrew P.</style></author><author><style face="normal" font="default" size="100%">Guasco, Timothy L.</style></author><author><style face="normal" font="default" size="100%">Ryder, Olivia S.</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Cuadra-Rodriguez, Luis A.</style></author><author><style face="normal" font="default" size="100%">Collins, Douglas B.</style></author><author><style face="normal" font="default" size="100%">Ruppel, Matthew J.</style></author><author><style face="normal" font="default" size="100%">Bertram, Timothy H.</style></author><author><style face="normal" font="default" size="100%">Prather, Kimberly A.</style></author><author><style face="normal" font="default" size="100%">Grassian, Vicki H.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inside versus Outside: Ion Redistribution in Nitric Acid Reacted Sea Spray Aerosol Particles as Determined by Single Particle Analysis.</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of the American Chemical Society</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ion redistribution sea spray aerosol particle nitric acid reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">single particle analysis monitoring ion redistribution sea spray aerosol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society</style></publisher><volume><style face="normal" font="default" size="100%">135</style></volume><pages><style face="normal" font="default" size="100%">14528 - 14531</style></pages><isbn><style face="normal" font="default" size="100%">0002-7863</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Single particle anal. of individual sea spray aerosol particles showed cations (Na+, K+, Mg2+, Ca2+) within individual particles undergo a spatial redistribution following heterogeneous reaction with HNO3, along with development of a more concd. layer of org. matter at the particle surface.  These data suggested specific ion and aerosol pH effects play an important role in aerosol particle structure in ways not previously recognized. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">39</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2013:1428969(Journal; Online Computer File)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kibombo, Harrison S.</style></author><author><style face="normal" font="default" size="100%">Wu, Chia-Ming</style></author><author><style face="normal" font="default" size="100%">Peng, Rui</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Koodali, Ranjit T.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Investigation of the role of platinum oxide for the degradation of phenol under simulated solar irradiation.</style></title><secondary-title><style face="normal" font="default" size="100%">Applied Catalysis, B: Environmental</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">platinum oxide titania photocatalyst phenol photodegrdn solar irradn</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year></dates><publisher><style face="normal" font="default" size="100%">Elsevier B.V.</style></publisher><volume><style face="normal" font="default" size="100%">136-137</style></volume><pages><style face="normal" font="default" size="100%">248 - 259</style></pages><isbn><style face="normal" font="default" size="100%">0926-3373</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The authors demonstrate that a desired oxidn. state can be achieved by synthetic colloidal methods and the choice of characterization technique is crucial for detg. the physicochem. properties that influence the photocatalytic activities.  XPS studies showed that PtO2 was realized in this study, and the resultant cryst. PtO2-TiO2 prepd. by subsequent hydrothermal treatment demonstrated activity for phenol degrdn. under simulated solar light irradn.  Preformed platinum based TiO2 ensures control over the oxidn. state and the crystallite size of titania.  The role of Ptox in the form of stable Pt4+ is elucidated as a mild recombination center, whereas the crystallite size of Pt in surfactant free Pt0-TiO2 appears to be the overriding factor for attaining enhanced photocatalytic performance. [on SciFinder(R)]</style></abstract><notes><style face="normal" font="default" size="100%">CAPLUS AN 2013:414160(Journal; Online Computer File)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hassan, Ihab H.</style></author><author><style face="normal" font="default" size="100%">Zhang, Michael S.</style></author><author><style face="normal" font="default" size="100%">Powers, Linda S.</style></author><author><style face="normal" font="default" size="100%">Shao, Jian Q.</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Rutkowski, D. Thomas</style></author><author><style face="normal" font="default" size="100%">Legge, Kevin</style></author><author><style face="normal" font="default" size="100%">Monick, Martha M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Influenza A Viral Replication Is Blocked by Inhibition of the Inositol-requiring Enzyme 1 (IRE1) Stress Pathway.</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Biological Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">influenza viral replication IRE1 stress pathway inhibition</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2012///</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">American Society for Biochemistry and Molecular Biology</style></publisher><volume><style face="normal" font="default" size="100%">287</style></volume><pages><style face="normal" font="default" size="100%">4679 - 4689</style></pages><isbn><style face="normal" font="default" size="100%">0021-9258</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Known therapies for influenza A virus infection are complicated by the frequent emergence of resistance.  A therapeutic strategy that may escape viral resistance is targeting host cellular mechanisms involved in viral replication and pathogenesis.  The endoplasmic reticulum (ER) stress response, also known as the unfolded protein response (UPR), is a primitive, evolutionary conserved mol. signaling cascade that has been implicated in multiple biol. phenomena including innate immunity and the pathogenesis of certain viral infections.  We investigated the effect of influenza A viral infection on ER stress pathways in lung epithelial cells.  Influenza A virus induced ER stress in a pathway-specific manner.  We showed that the virus activates the IRE1 pathway with little or no concomitant activation of the PERK and the ATF6 pathways.  When we examd. the effects of modulating the ER stress response on the virus, we found that the mol. chaperone tauroursodeoxycholic acid (TUDCA) significantly inhibits influenza A viral replication.  In addn., a specific inhibitor of the IRE1 pathway also blocked viral replication.  Our findings constitute the first evidence that ER stress plays a role in the pathogenesis of influenza A viral infection.  Decreasing viral replication by modulating the host ER stress response is a novel strategy that has important therapeutic implications. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">7</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2012:212308(Journal; Online Computer File)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Reisetter, Anna C.</style></author><author><style face="normal" font="default" size="100%">Stebounova, Larissa V.</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Powers, Linda</style></author><author><style face="normal" font="default" size="100%">Gupta, Amit</style></author><author><style face="normal" font="default" size="100%">Grassian, Vicki H.</style></author><author><style face="normal" font="default" size="100%">Monick, Martha M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Induction of Inflammasome-dependent Pyroptosis by Carbon Black Nanoparticles.</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Biological Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">carbon black nanoparticle immunotoxicity inflammasome pyroptosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011///</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">American Society for Biochemistry and Molecular Biology</style></publisher><volume><style face="normal" font="default" size="100%">286</style></volume><pages><style face="normal" font="default" size="100%">21844 - 21852</style></pages><isbn><style face="normal" font="default" size="100%">0021-9258</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Inhalation of nanoparticles has been implicated in respiratory morbidity and mortality.  In particular, carbon black nanoparticles are found in many different environmental exposures.  Macrophages take up inhaled nanoparticles and respond via release of inflammatory mediators and in some cases cell death.  Based on new data, we propose that exposure of macrophages (both a macrophage cell line and primary human alveolar macrophages) to carbon black nanoparticles induces pyroptosis, an inflammasome-dependent form of cell death.  Exposure of macrophages to carbon black nanoparticles resulted in inflammasome activation as defined by cleavage of caspase 1 to its active form and downstream IL-1β release.  The cell death that occurred with carbon black nanoparticle exposure was identified as pyroptosis by the protective effect of a caspase 1 inhibitor and a pyroptosis inhibitor.  These data demonstrate that carbon black nanoparticle exposure activates caspase 1, increases IL-1β release after LPS priming, and induces the proinflammatory cell death, pyroptosis.  The identification of pyroptosis as a cellular response to carbon nanoparticle exposure is novel and relates to environmental and health impacts of carbon-based particulates. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">24</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2011:737835(Journal)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kiss, Peter J.</style></author><author><style face="normal" font="default" size="100%">Knisz, Judit</style></author><author><style face="normal" font="default" size="100%">Zhang, Yuzhou</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Sigmund, Curt D.</style></author><author><style face="normal" font="default" size="100%">Thalmann, Ruediger</style></author><author><style face="normal" font="default" size="100%">Smith, Richard J. H.</style></author><author><style face="normal" font="default" size="100%">Verpy, Elisabeth</style></author><author><style face="normal" font="default" size="100%">Banfi, Botond.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inactivation of NADPH oxidase organizer 1 Results in Severe Imbalance.</style></title><secondary-title><style face="normal" font="default" size="100%">Current Biology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">NADPH oxidase organizer 1 otoconia formation balance deficit</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006///</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">Cell Press</style></publisher><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">208 - 213</style></pages><isbn><style face="normal" font="default" size="100%">0960-9822</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Otoconia are biominerals of the vestibular system that are indispensable for the perception of gravity.  Despite their importance, the process of otoconia genesis is largely unknown.  Reactive oxygen species (ROS) have been recognized for their toxic effects in antimicrobial host defense as well as in aging and carcinogenesis.  Enzymes evolved for ROS prodn. belong to the recently discovered NADPH oxidase (Nox) enzyme family.  Here we show that the inactivation of a regulatory subunit, NADPH oxidase organizer 1 (Noxo1), resulted in the severe balance deficit seen in the spontaneous mutant &quot;head slant&quot; (hslt) mice whose phenotype was rescued by Noxo1 transgenes.  Wild-type Noxo1 was expressed in the vestibular and cochlear epithelia and was required for ROS prodn. by an oxidase complex.  In contrast, the hslt mutation of Noxo1 was biochem. inactive and led to an arrest of otoconia genesis, characterized by a complete lack of calcium carbonate mineralization and an accumulation of otoconial protein, otoconin-90/95 (OC-90/95).  These results suggest that ROS generated by a Noxo1-dependent vestibular oxidase are crit. for otoconia formation and may be required for interactions among otoconial components.  Noxo1 mutants implicate a constructive developmental role for ROS, in contrast to their previously described toxic effects. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2006:87961(Journal)</style></notes></record></records></xml>