<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lee, Chiwook</style></author><author><style face="normal" font="default" size="100%">Sohn, Jae Hak</style></author><author><style face="normal" font="default" size="100%">Jang, Jae-Hyuk</style></author><author><style face="normal" font="default" size="100%">Ahn, Jong Seog</style></author><author><style face="normal" font="default" size="100%">Oh, Hyuncheol</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Hwang, In Hyun</style></author><author><style face="normal" font="default" size="100%">Gloer, James B.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cycloexpansamines A and B: spiroindolinone alkaloids from a marine isolate of Penicillium sp. (SF-5292).</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Antibiotics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">cycloexpansamine Penicillium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year></dates><publisher><style face="normal" font="default" size="100%">Nature Publishing Group</style></publisher><volume><style face="normal" font="default" size="100%">68</style></volume><pages><style face="normal" font="default" size="100%">715 - 718</style></pages><isbn><style face="normal" font="default" size="100%">0021-8820</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Cycloexpansamines A (I) and B (II) were isolated from the title fungus and characterized. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">11</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2015:1911729(Journal; Online Computer File)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kolodziej, Edward P.</style></author><author><style face="normal" font="default" size="100%">Qu, Shen</style></author><author><style face="normal" font="default" size="100%">Forsgren, Kristy L.</style></author><author><style face="normal" font="default" size="100%">Long, Sarah A.</style></author><author><style face="normal" font="default" size="100%">Gloer, James B.</style></author><author><style face="normal" font="default" size="100%">Jones, Gerrad D.</style></author><author><style face="normal" font="default" size="100%">Schlenk, Daniel</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Cwiertny, David M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification and Environmental Implications of Photo-Transformation Products of Trenbolone Acetate Metabolites.</style></title><secondary-title><style face="normal" font="default" size="100%">Environmental Science &amp; Technology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">photodegrdn trenbolone acetate metabolite Oryzias ecotoxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society</style></publisher><volume><style face="normal" font="default" size="100%">47</style></volume><pages><style face="normal" font="default" size="100%">5031 - 5041</style></pages><isbn><style face="normal" font="default" size="100%">0013-936X</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Despite the widespread use of the anabolic androgen trenbolone acetate (TBA) in animal agriculture, evidence demonstrating the occurrence of TBA metabolites such as 17β-trenbolone (17β-TBOH), 17α-trenbolone (17α-TBOH), and trendione (TBO) is relatively scarce, potentially due to rapid transformation processes such as direct photolysis.  Therefore, we investigated the phototransformation of TBA metabolites and assocd. ecol. implications by characterizing the photoproducts arising from the direct photolysis of 17β-TBOH, 17α-TBOH, and TBO and their assocd. ecotoxicity.  LC-HRMS/MS anal. identified a range of hydroxylated products that were no longer photoactive, with primary photoproducts consisting of monohydroxy species and presumptive diastereomers.  Also obsd. were higher-order hydroxylated products probably formed via subsequent reaction of primary photoproducts.  NMR anal. confirmed the formation of 12,17-dihydroxy-estra-5(10),9(11),dien-3-one (12-hydroxy-TBOH; 2.2 mg), 10,12,17-trihydroxy-estra-4,9(11),dien-3-one (10,12-dihydroxy-TBOH; 0.7 mg), and a ring-opened 11,12-dialdehyde oxidn. product (TBOH-11,12-dialdehyde; 1.0 mg) after irradn. of ∼14 mg of 17β-trenbolone.  Though unconfirmed by NMR, our data suggest that the formation of addnl. isomeric products may occur, likely due to the reactivity of the unique 4,9,11 conjugated triene structure of trenbolone.  In vivo exposure studies employing Japanese medaka (Oryzias latipes) indicate that low concns. of 17α-TBOH photoproduct mixts. can alter ovarian follicular development, and photoproducts alter whole-body 17β-estradiol levels.  Therefore, direct photolysis yields photoproducts with strong structural similarity to parent steroids, and these photoproducts still retain enough biol. activity to elicit observable changes to endocrine function at trace concns.  These data indicate that environmental transformation processes do not necessarily reduce steroid hormone ecotoxicity. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">10</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2013:623700(Journal; Online Computer File)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Qu, Shen</style></author><author><style face="normal" font="default" size="100%">Kolodziej, Edward P.</style></author><author><style face="normal" font="default" size="100%">Long, Sarah A.</style></author><author><style face="normal" font="default" size="100%">Gloer, James B.</style></author><author><style face="normal" font="default" size="100%">Patterson, Eric V.</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Jones, Gerrad D.</style></author><author><style face="normal" font="default" size="100%">Benchetler, Peter V.</style></author><author><style face="normal" font="default" size="100%">Cole, Emily A.</style></author><author><style face="normal" font="default" size="100%">Kimbrough, Kaitlin C.</style></author><author><style face="normal" font="default" size="100%">Tarnoff, Matthew D.</style></author><author><style face="normal" font="default" size="100%">Cwiertny, David M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Product-to-parent reversion of trenbolone: Unrecognized risks for endocrine disruption.</style></title><secondary-title><style face="normal" font="default" size="100%">Science (Washington, DC, United States)</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">trenbolone metabolite reversion endocrine disruption environment risk</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year></dates><publisher><style face="normal" font="default" size="100%">American Association for the Advancement of Science</style></publisher><volume><style face="normal" font="default" size="100%">342</style></volume><pages><style face="normal" font="default" size="100%">347 - 351</style></pages><isbn><style face="normal" font="default" size="100%">0036-8075</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Trenbolone acetate (TBA) is a high-value steroidal growth promoter often administered to beef cattle, whose metabolites are potent endocrine-disrupting compds.  We performed lab. and field phototransformation expts. to assess the fate of TBA metabolites and their photoproducts.  Unexpectedly, we obsd. that the rapid photohydration of TBA metabolites is reversible under conditions representative of those in surface waters (pH 7, 25°C).  This product-to-parent reversion mechanism results in diurnal cycling and substantial regeneration of TBA metabolites at rates that are strongly temp.- and pH-dependent.  Photoproducts can also react to produce structural analogs of TBA metabolites.  These reactions also occur in structurally similar steroids, including human pharmaceuticals, which suggests that predictive fate models and regulatory risk assessment paradigms must account for transformation products of high-risk environmental contaminants such as endocrine-disrupting steroids. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">6156</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2013:1616444(Journal)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neff, Scott A.</style></author><author><style face="normal" font="default" size="100%">Lee, Sang Un</style></author><author><style face="normal" font="default" size="100%">Asami, Yukihiro</style></author><author><style face="normal" font="default" size="100%">Ahn, Jong Seog</style></author><author><style face="normal" font="default" size="100%">Oh, Hyuncheol</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Gloer, James B.</style></author><author><style face="normal" font="default" size="100%">Wicklow, Donald T.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Aflaquinolones A-G: Secondary metabolites from marine and fungicolous isolates of Aspergillus spp.</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Natural Products</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">aflaquinolone Aspergillus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society-American Society of Pharmacognosy</style></publisher><volume><style face="normal" font="default" size="100%">75</style></volume><pages><style face="normal" font="default" size="100%">464 - 472</style></pages><isbn><style face="normal" font="default" size="100%">0163-3864</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Seven new compds. (aflaquinolones A-G; 1-7) contg. dihydroquinolin-2-one and terpenoid units have been isolated from two different fungal sources.  Two of these metabolites (1 and 2) were obtained from a Hawaiian fungicolous isolate of Aspergillus sp. (section Flavipedes; MYC-2048 = NRRL 58570), while the others were obtained from a marine Aspergillus isolate (SF-5044) collected in Korea.  The structures of these compds. were detd. mainly by anal. of NMR and MS data.  Relative and abs. configurations were assigned on the basis of NOESY data and 1H NMR J-values, comparison of calcd. and exptl. ECD spectra, and anal. of a Mosher's ester deriv. of 2.  Several known compds., including alantrypinone, aspochalasins I and J, Me 3,4,5-trimethoxy-2((2-((3-pyridinylcarbonyl)amino)benzoyl)amino)benzoate, and trans-dehydrocurvularin were also encountered in the ext. of the Hawaiian isolate. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2012:163288(Journal; Online Computer File)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shim, Sang Hee</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Gloer, James B.</style></author><author><style face="normal" font="default" size="100%">Wicklow, Donald T.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phomalevones A-C: Dimeric and pseudodimeric polyketides from a fungicolous Hawaiian isolate of Phoma sp. (Cucurbitariaceae).</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Natural Products</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">phomalevone Phoma</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011///</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society-American Society of Pharmacognosy</style></publisher><volume><style face="normal" font="default" size="100%">74</style></volume><pages><style face="normal" font="default" size="100%">395 - 401</style></pages><isbn><style face="normal" font="default" size="100%">0163-3864</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Phomalevones A-C (1-3), three new compds. with bis-dihydroxanthone and bis-benzophenone systems, were isolated from cultures of a Hawaiian isolate of Phoma sp. (MYC-1734 = NRRL 39060; Cucurbitariaceae).  The structures of 1-3 were detd. by anal. of NMR and MS data.  The abs. configurations of the sp3 stereocenters in the monomeric unit of 1 were assigned by application of Mosher's method, and overall abs. configurations were proposed on the basis of ECD data using both computational methods and comparisons with literature data for model compds.  All three compds. showed antibacterial activity, and compds. 2 and 3 also exhibited antifungal effects. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2011:84225(Journal; Online Computer File)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Schmidt, Lori E.</style></author><author><style face="normal" font="default" size="100%">Deyrup, Stephen T.</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Swenson, Dale C.</style></author><author><style face="normal" font="default" size="100%">Wicklow, Donald T.</style></author><author><style face="normal" font="default" size="100%">Gloer, James B.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hymenopsins A and B and a macrophorin analog from a fungicolous Hymenopsis sp.</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Natural Products</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">hymenopsin Hymenopsis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2010</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2010///</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society-American Society of Pharmacognosy</style></publisher><volume><style face="normal" font="default" size="100%">73</style></volume><pages><style face="normal" font="default" size="100%">404 - 408</style></pages><isbn><style face="normal" font="default" size="100%">0163-3864</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Hymenopsin A (1), hymenopsin B (2), and a new macrophorin analog, 2',3'-epoxy-13-hydroxy-4'-oxomacrophorin A (3), have been isolated from a fungicolous isolate of Hymenopsis sp. (MYC-1703; NRRL 37638).  The structures and relative configurations of these compds. were assigned on the basis of 2D NMR and MS data, and the identity of 1 was confirmed by X-ray crystallog. anal.  The abs. configuration of 2 was proposed on the basis of CD anal. using both empirical and computational methods.  Compds. 2 and 3 showed antibacterial activity against Staphylococcus aureus and Bacillus subtilis.  Compd. 3 was also active against Aspergillus flavus and Fusarium verticillioides. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2009:1462186(Journal)</style></notes></record></records></xml>