<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Qu, Shen</style></author><author><style face="normal" font="default" size="100%">Kolodziej, Edward P.</style></author><author><style face="normal" font="default" size="100%">Long, Sarah A.</style></author><author><style face="normal" font="default" size="100%">Gloer, James B.</style></author><author><style face="normal" font="default" size="100%">Patterson, Eric V.</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Jones, Gerrad D.</style></author><author><style face="normal" font="default" size="100%">Benchetler, Peter V.</style></author><author><style face="normal" font="default" size="100%">Cole, Emily A.</style></author><author><style face="normal" font="default" size="100%">Kimbrough, Kaitlin C.</style></author><author><style face="normal" font="default" size="100%">Tarnoff, Matthew D.</style></author><author><style face="normal" font="default" size="100%">Cwiertny, David M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Product-to-parent reversion of trenbolone: Unrecognized risks for endocrine disruption.</style></title><secondary-title><style face="normal" font="default" size="100%">Science (Washington, DC, United States)</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">trenbolone metabolite reversion endocrine disruption environment risk</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year></dates><publisher><style face="normal" font="default" size="100%">American Association for the Advancement of Science</style></publisher><volume><style face="normal" font="default" size="100%">342</style></volume><pages><style face="normal" font="default" size="100%">347 - 351</style></pages><isbn><style face="normal" font="default" size="100%">0036-8075</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Trenbolone acetate (TBA) is a high-value steroidal growth promoter often administered to beef cattle, whose metabolites are potent endocrine-disrupting compds.  We performed lab. and field phototransformation expts. to assess the fate of TBA metabolites and their photoproducts.  Unexpectedly, we obsd. that the rapid photohydration of TBA metabolites is reversible under conditions representative of those in surface waters (pH 7, 25°C).  This product-to-parent reversion mechanism results in diurnal cycling and substantial regeneration of TBA metabolites at rates that are strongly temp.- and pH-dependent.  Photoproducts can also react to produce structural analogs of TBA metabolites.  These reactions also occur in structurally similar steroids, including human pharmaceuticals, which suggests that predictive fate models and regulatory risk assessment paradigms must account for transformation products of high-risk environmental contaminants such as endocrine-disrupting steroids. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">6156</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2013:1616444(Journal)</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shim, Sang Hee</style></author><author><style face="normal" font="default" size="100%">Baltrusaitis, Jonas</style></author><author><style face="normal" font="default" size="100%">Gloer, James B.</style></author><author><style face="normal" font="default" size="100%">Wicklow, Donald T.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phomalevones A-C: Dimeric and pseudodimeric polyketides from a fungicolous Hawaiian isolate of Phoma sp. (Cucurbitariaceae).</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Natural Products</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">phomalevone Phoma</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011///</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society-American Society of Pharmacognosy</style></publisher><volume><style face="normal" font="default" size="100%">74</style></volume><pages><style face="normal" font="default" size="100%">395 - 401</style></pages><isbn><style face="normal" font="default" size="100%">0163-3864</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Phomalevones A-C (1-3), three new compds. with bis-dihydroxanthone and bis-benzophenone systems, were isolated from cultures of a Hawaiian isolate of Phoma sp. (MYC-1734 = NRRL 39060; Cucurbitariaceae).  The structures of 1-3 were detd. by anal. of NMR and MS data.  The abs. configurations of the sp3 stereocenters in the monomeric unit of 1 were assigned by application of Mosher's method, and overall abs. configurations were proposed on the basis of ECD data using both computational methods and comparisons with literature data for model compds.  All three compds. showed antibacterial activity, and compds. 2 and 3 also exhibited antifungal effects. [on SciFinder(R)]</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><notes><style face="normal" font="default" size="100%">CAPLUS AN 2011:84225(Journal; Online Computer File)</style></notes></record></records></xml>