Bactericidal effect of graphene oxide/Cu/Ag nanoderivatives against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus.

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TitleBactericidal effect of graphene oxide/Cu/Ag nanoderivatives against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus.
Publication TypeJournal Article
Year of Publication2016
JournalInternational Journal of Pharmaceutics (Amsterdam, Netherlands)
Volume511
Issue1
Pagination90 - 97
AuthorsJankauskaite, V., A. Vitkauskiene, A. Lazauskas, J. Baltrusaitis, I. Prosycevas, and M. Andrulevicius
PublisherElsevier B.V.
ISBN Number0378-5173
Keywordsantibacterial graphene oxide copper silver nanocomposite
Abstract

A systematic anal. of antibacterial activity of individual nanoderivatives, e.g. GO nanosheets, Ag and Cu nanoparticles (NPs), as well as combinations of Cu-Ag NPs, and GO-Cu-Ag nanocomposites against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) was performed. Chem. properties of the GO, Cu and Ag NPs were detd. employing XPS and X-Ray-excited Auger electron spectroscopy. Morphol. of corresponding nanoderivatives was studied employing transmission electron microscopy and SEM. It was shown that combination of Cu and Ag NPs, as well as GO-Cu-Ag nanocomposite material possess enhanced antibacterial activity through a possible synergy between multiple toxicity mechanisms. MRSA showed highest resistance in all cases. [on SciFinder(R)]