| Title | Development of Electrically Conductive Oligo(polyethylene glycol) Fumarate-Polypyrrole Hydrogels for Nerve Regeneration. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Journal | Biomacromolecules |
| Volume | 11 |
| Issue | 11 |
| Pagination | 2845 - 2853 |
| Authors | M. Runge, Brett, Mahrokh Dadsetan, Jonas Baltrusaitis, Terry Ruesink, Lichun Lu, Anthony J. Windebank, and Michael J. Yaszemski |
| Publisher | American Chemical Society |
| ISBN Number | 1525-7797 |
| Keywords | elec conductive oligopolyethylene glycol fumarate polypyrrole hydrogel nerve regeneration |
| Abstract | Elec. conductive hydrogel composites consisting of oligo(polyethylene glycol) fumarate (OPF) and polypyrrole (PPy) were developed for applications in nerve regeneration. OPF-PPy scaffolds were synthesized using three different anions: naphthalene-2-sulfonic acid sodium salt (NSA), dodecylbenzenesulfonic acid sodium salt (DBSA), and dioctyl sulfosuccinate sodium salt (DOSS). Scaffolds were characterized by ATR-FTIR, XPS, AFM, dynamic mech. anal., elec. resistivity measurements, and swelling expts. OPF-PPy scaffolds were shown to consist of up to 25 mol % polypyrrole with a compressive modulus ranging from 265 to 323 kPa and a sheet resistance ranging from 6 to 30 × 103 Ohms/square. In vitro studies using PC12 cells showed OPF-PPy materials had no cytotoxicity and PC12 cells showed distinctly better cell attachment and an increase in the percent of neurite bearing cells on OPF-PPy materials compared to OPF. The neurite lengths of PC12 cells were significantly higher on OPF-PPyNSA and OPF-PPyDBSA. These results show that elec. conductive OPF-PPy hydrogels are promising candidates for future applications in nerve regeneration. [on SciFinder(R)] |