baltrusaitis lab @ lehigh

Phomalevones A-C: Dimeric and pseudodimeric polyketides from a fungicolous Hawaiian isolate of Phoma sp. (Cucurbitariaceae).

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  3. Phomalevones A-C: Dimeric and pseudodimeric polyketides from a fungicolous Hawaiian isolate of Phoma sp. (Cucurbitariaceae).
TitlePhomalevones A-C: Dimeric and pseudodimeric polyketides from a fungicolous Hawaiian isolate of Phoma sp. (Cucurbitariaceae).
Publication TypeJournal Article
Year of Publication2011
JournalJournal of Natural Products
Volume74
Issue3
Pagination395 - 401
AuthorsShim, Sang Hee, Jonas Baltrusaitis, James B. Gloer, and Donald T. Wicklow
PublisherAmerican Chemical Society-American Society of Pharmacognosy
ISBN Number0163-3864
Keywordsphomalevone Phoma
Abstract

Phomalevones A-C (1-3), three new compds. with bis-dihydroxanthone and bis-benzophenone systems, were isolated from cultures of a Hawaiian isolate of Phoma sp. (MYC-1734 = NRRL 39060; Cucurbitariaceae). The structures of 1-3 were detd. by anal. of NMR and MS data. The abs. configurations of the sp3 stereocenters in the monomeric unit of 1 were assigned by application of Mosher's method, and overall abs. configurations were proposed on the basis of ECD data using both computational methods and comparisons with literature data for model compds. All three compds. showed antibacterial activity, and compds. 2 and 3 also exhibited antifungal effects. [on SciFinder(R)]